The Effect of Thiamine and Vitamin C Combination on Mortality Rate of Patients with Severe Sepsis: A Randomized Control Clinical Trial Study

Name: The Effect of Thiamine and Vitamin C Combination on Mortality Rate of Patients with Severe Sepsis: A Randomized Control Clinical Trial Study
Author: Kiana Shirani, Rasool Soltani, Yasaman Eskandari, Hasan Salehi

İsim	The Effect of Thiamine and Vitamin C Combination on Mortality Rate of Patients with Severe Sepsis: A Randomized Control Clinical Trial Study
Yazar	Kiana Shirani, Rasool Soltani, Yasaman Eskandari, Hasan Salehi
Basım Tarihi:	1401
Basım Yeri	- Isfahan University of Medical Sciences, 1401.
Konu	ascorbic acid, mortality, procalcitonin, sepsis, thiamine, Medicine, Medicine (General), R5-920
Tür	Süreli Yayın
Dil	Farsça
Dijital	Evet
Yazma	Hayır
Fiziksel Boyutlar	electronic resource
Kütüphane:	Bursa Uludağ Üniversitesi Kütüphanesi
Demirbaş Numarası	edsdoj.7314461cebbe4879a120d29e010f984d
Kayıt Numarası	cyeo6zyufb
Lokasyon	LCC:Medicine, LCC:Medicine (General)
Tarih	1401
Örnek Metin	Background: Sepsis is a potentially life-threatening condition characterized by the body's deregulated response to infection, in turn causing injury to its own tissues and organs. The present study investigated the effect of co-administration of thiamine and vitamin C on reducing mortality in patients with severe sepsis.Methods: In this randomized clinical trial study, 86 patients with severe sepsis were assigned to treatment and control groups, each comprising 43 patients. The treatment group received thiamine 600 mg orally every 12 hours and vitamin C at a dose of 50 mg / kg, intravenously daily for 96 hours alongside standard treatment and the control group received standard treatment. Therapeutic outcome (recovery or death), duration of hospitalization and duration of ventilator connection were recorded for patients in both groups. Also, procalcitonin level (PCT) and CRP levels were measured and recorded at the beginning and after 96 hours.Findings: The odds ratio of death outcome in the treatment group was significantly lower than the control group (0.913-0.116: 95% CI, P = 0.033, OR = 0.32). The mean length of hospital stay in the treatment group was about 7 days that was less than the control group significantly. The mean length of ICU hospitalization in the treatment group was less than the control group significantly too.Conclusion: Co-administration of vitamin C and thiamine in sepsis patients can reduce the length of hospital stay in the intensive care unit and hospital and also reduce the serum level of inflammatory factors and reduce the rate of death in these patients.
DOI	10.48305/jims.v40.i691.0825
ISSN	1027-7595, 1735-854X
İlişki	https://jims.mui.ac.ir/article_26275_713b521d4d5b06f9cda40ebb149b0d5e.pdf; https://doaj.org/toc/1027-7595; https://doaj.org/toc/1735-854X

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The Effect of Thiamine and Vitamin C Combination on Mortality Rate of Patients with Severe Sepsis: A Randomized Control Clinical Trial Study

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The Effect of Thiamine and Vitamin C Combination on Mortality Rate of Patients with Severe Sepsis: A Randomized Control Clinical Trial Study

Yazar Kiana Shirani, Rasool Soltani, Yasaman Eskandari, Hasan Salehi

Basım Tarihi 1401

Basım Yeri - Isfahan University of Medical Sciences, 1401.

Konu ascorbic acid, mortality, procalcitonin, sepsis, thiamine, Medicine, Medicine (General), R5-920

Tür Süreli Yayın

Dil Farsça

Dijital Evet

Yazma Hayır

Fiziksel Boyutlar electronic resource

Kütüphane Bursa Uludağ Üniversitesi Kütüphanesi

Demirbaş Numarası edsdoj.7314461cebbe4879a120d29e010f984d

Kayıt Numarası cyeo6zyufb

Lokasyon LCC:Medicine, LCC:Medicine (General)

Tarih 1401

Örnek Metin Background: Sepsis is a potentially life-threatening condition characterized by the body's deregulated response to infection, in turn causing injury to its own tissues and organs. The present study investigated the effect of co-administration of thiamine and vitamin C on reducing mortality in patients with severe sepsis.Methods: In this randomized clinical trial study, 86 patients with severe sepsis were assigned to treatment and control groups, each comprising 43 patients. The treatment group received thiamine 600 mg orally every 12 hours and vitamin C at a dose of 50 mg / kg, intravenously daily for 96 hours alongside standard treatment and the control group received standard treatment. Therapeutic outcome (recovery or death), duration of hospitalization and duration of ventilator connection were recorded for patients in both groups. Also, procalcitonin level (PCT) and CRP levels were measured and recorded at the beginning and after 96 hours.Findings: The odds ratio of death outcome in the treatment group was significantly lower than the control group (0.913-0.116: 95% CI, P = 0.033, OR = 0.32). The mean length of hospital stay in the treatment group was about 7 days that was less than the control group significantly. The mean length of ICU hospitalization in the treatment group was less than the control group significantly too.Conclusion: Co-administration of vitamin C and thiamine in sepsis patients can reduce the length of hospital stay in the intensive care unit and hospital and also reduce the serum level of inflammatory factors and reduce the rate of death in these patients.

DOI 10.48305/jims.v40.i691.0825

ISSN 1027-7595, 1735-854X

İlişki https://jims.mui.ac.ir/article_26275_713b521d4d5b06f9cda40ebb149b0d5e.pdf; https://doaj.org/toc/1027-7595; https://doaj.org/toc/1735-854X

The Effect of Thiamine and Vitamin C Combination on Mortality Rate of Patients with Severe Sepsis: A Randomized Control Clinical Trial Study

Diğer Nüshalar

The Effect of Thiamine and Vitamin C Combination on Mortality Rate of Patients with Severe Sepsis: A Randomized Control Clinical Trial Study

The Effect of Thiamine and Vitamin C Combination on Mortality Rate of Patients with Severe Sepsis: A Randomized Control Clinical Trial Study

Diğer Nüshalar

The Effect of Thiamine and Vitamin C ...