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The Effect of Thiamine and Vitamin C Combination on Mortality Rate of Patients with Severe Sepsis: A Randomized Control Clinical Trial Study

Title	The Effect of Thiamine and Vitamin C Combination on Mortality Rate of Patients with Severe Sepsis: A Randomized Control Clinical Trial Study
Author	Kiana Shirani, Rasool Soltani, Yasaman Eskandari, Hasan Salehi
Publication Date:	1401
Publication Place	- Isfahan University of Medical Sciences, 1401.
Subject	ascorbic acid, mortality, procalcitonin, sepsis, thiamine, Medicine, Medicine (General), R5-920
Type	Periodical
Language	Persian
Digital	Yes
Manuscript	No
Physical Dimensions	electronic resource
Library:	Bursa Uludağ University Library
Library Asset ID	edsdoj.7314461cebbe4879a120d29e010f984d
Record ID	cyeo6zyufb
Library Location	LCC:Medicine, LCC:Medicine (General)
Date	1401
Sample Text	Background: Sepsis is a potentially life-threatening condition characterized by the body's deregulated response to infection, in turn causing injury to its own tissues and organs. The present study investigated the effect of co-administration of thiamine and vitamin C on reducing mortality in patients with severe sepsis.Methods: In this randomized clinical trial study, 86 patients with severe sepsis were assigned to treatment and control groups, each comprising 43 patients. The treatment group received thiamine 600 mg orally every 12 hours and vitamin C at a dose of 50 mg / kg, intravenously daily for 96 hours alongside standard treatment and the control group received standard treatment. Therapeutic outcome (recovery or death), duration of hospitalization and duration of ventilator connection were recorded for patients in both groups. Also, procalcitonin level (PCT) and CRP levels were measured and recorded at the beginning and after 96 hours.Findings: The odds ratio of death outcome in the treatment group was significantly lower than the control group (0.913-0.116: 95% CI, P = 0.033, OR = 0.32). The mean length of hospital stay in the treatment group was about 7 days that was less than the control group significantly. The mean length of ICU hospitalization in the treatment group was less than the control group significantly too.Conclusion: Co-administration of vitamin C and thiamine in sepsis patients can reduce the length of hospital stay in the intensive care unit and hospital and also reduce the serum level of inflammatory factors and reduce the rate of death in these patients.
DOI	10.48305/jims.v40.i691.0825
ISSN	1027-7595, 1735-854X
İlişki	https://jims.mui.ac.ir/article_26275_713b521d4d5b06f9cda40ebb149b0d5e.pdf; https://doaj.org/toc/1027-7595; https://doaj.org/toc/1735-854X

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Record ID: 4229290

Bursa Uludağ University Library

The Effect of Thiamine and Vitamin C Combination on Mortality Rate of Patients with Severe Sepsis: A Randomized Control Clinical Trial Study

Author Kiana Shirani, Rasool Soltani, Yasaman Eskandari, Hasan Salehi

Publication Date 1401

Publication Place - Isfahan University of Medical Sciences, 1401.

Subject ascorbic acid, mortality, procalcitonin, sepsis, thiamine, Medicine, Medicine (General), R5-920

Type Periodical

Language Persian

Digital Yes

Manuscript No

Physical Dimensions electronic resource

Library Bursa Uludağ University Library

Library Asset ID edsdoj.7314461cebbe4879a120d29e010f984d

Record ID cyeo6zyufb

Library Location LCC:Medicine, LCC:Medicine (General)

Date 1401

Sample Text Background: Sepsis is a potentially life-threatening condition characterized by the body's deregulated response to infection, in turn causing injury to its own tissues and organs. The present study investigated the effect of co-administration of thiamine and vitamin C on reducing mortality in patients with severe sepsis.Methods: In this randomized clinical trial study, 86 patients with severe sepsis were assigned to treatment and control groups, each comprising 43 patients. The treatment group received thiamine 600 mg orally every 12 hours and vitamin C at a dose of 50 mg / kg, intravenously daily for 96 hours alongside standard treatment and the control group received standard treatment. Therapeutic outcome (recovery or death), duration of hospitalization and duration of ventilator connection were recorded for patients in both groups. Also, procalcitonin level (PCT) and CRP levels were measured and recorded at the beginning and after 96 hours.Findings: The odds ratio of death outcome in the treatment group was significantly lower than the control group (0.913-0.116: 95% CI, P = 0.033, OR = 0.32). The mean length of hospital stay in the treatment group was about 7 days that was less than the control group significantly. The mean length of ICU hospitalization in the treatment group was less than the control group significantly too.Conclusion: Co-administration of vitamin C and thiamine in sepsis patients can reduce the length of hospital stay in the intensive care unit and hospital and also reduce the serum level of inflammatory factors and reduce the rate of death in these patients.

DOI 10.48305/jims.v40.i691.0825

ISSN 1027-7595, 1735-854X

İlişki https://jims.mui.ac.ir/article_26275_713b521d4d5b06f9cda40ebb149b0d5e.pdf; https://doaj.org/toc/1027-7595; https://doaj.org/toc/1735-854X

Other Editions

The Effect of Thiamine and Vitamin C ... Record ID: 4229290