An exploration of new avenues regarding deep tissue penetration and higher singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic therapy

Name: An exploration of new avenues regarding deep tissue penetration and higher singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic therapy
Author: Yeşilgül, N., Kılıç, Bilal

İsim	An exploration of new avenues regarding deep tissue penetration and higher singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic therapy
Yazar	Yeşilgül, N., Kılıç, Bilal
Basım Tarihi:	2019
Basım Yeri	- TÜBİTAK
Konu	BODIPY, Photosensitizer, Photodynamic therapy, Singlet oxygen, Near-IR photosensitizer
Tür	Süreli Yayın
Dil	İngilizce
Dijital	Evet
Yazma	Hayır
Kütüphane:	Özyeğin Üniversitesi
Demirbaş Numarası	1300-0527
Kayıt Numarası	9bf187f8-3237-465a-b9ca-2c1810e2ab3c
Lokasyon	Professional Flight Program
Tarih	2019
Notlar	Department of Chemistry, Bilkent University ; UNAM, Bilkent University ; Faculty of Aviation and Aeronautical Science, Ozyegin University
Örnek Metin	A series of novel BODIPY-bearing electron-withdrawing groups at the meso position are reported here. According to the optical measurements, it may be clearly seen that the introduction of electron-donating groups into 3,5-positions and the presence of electron-withdrawing groups at the meso position of the BODIPY core resulted in spectacular bathochromic shifts (up to similar to 304 nm), and the projected photosensitizers had absorption bands in the therapeutic window of the electromagnetic spectrum (600-900 nm). The absorption maxima of compounds 4, 5, 6, and 7 were at 886 nm, 890 nm, 760 nm, and 761 nm, respectively. The singlet oxygen generation experiments revealed that compounds 6 and 7, with high singlet oxygen quantum yields (0.52 and 0.93, respectively), were excellent and promising candidates for photodynamic therapy. The singlet oxygen quantum yield of 0.93 was the highest reported value so far for BODIPY-based photosensitizers.
Cilt	43

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An exploration of new avenues regarding deep tissue penetration and higher singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic therapy

Yazar Yeşilgül, N., Kılıç, Bilal

Basım Tarihi 2019

Basım Yeri - TÜBİTAK

Konu BODIPY, Photosensitizer, Photodynamic therapy, Singlet oxygen, Near-IR photosensitizer

Tür Süreli Yayın

Dil İngilizce

Dijital Evet

Yazma Hayır

Kütüphane Özyeğin Üniversitesi

Demirbaş Numarası 1300-0527

Kayıt Numarası 9bf187f8-3237-465a-b9ca-2c1810e2ab3c

Lokasyon Professional Flight Program

Tarih 2019

Notlar Department of Chemistry, Bilkent University ; UNAM, Bilkent University ; Faculty of Aviation and Aeronautical Science, Ozyegin University

Örnek Metin A series of novel BODIPY-bearing electron-withdrawing groups at the meso position are reported here. According to the optical measurements, it may be clearly seen that the introduction of electron-donating groups into 3,5-positions and the presence of electron-withdrawing groups at the meso position of the BODIPY core resulted in spectacular bathochromic shifts (up to similar to 304 nm), and the projected photosensitizers had absorption bands in the therapeutic window of the electromagnetic spectrum (600-900 nm). The absorption maxima of compounds 4, 5, 6, and 7 were at 886 nm, 890 nm, 760 nm, and 761 nm, respectively. The singlet oxygen generation experiments revealed that compounds 6 and 7, with high singlet oxygen quantum yields (0.52 and 0.93, respectively), were excellent and promising candidates for photodynamic therapy. The singlet oxygen quantum yield of 0.93 was the highest reported value so far for BODIPY-based photosensitizers.

Cilt 43