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An exploration of new avenues regarding deep tissue penetration and higher singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic therapy

Title	An exploration of new avenues regarding deep tissue penetration and higher singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic therapy
Author	Yeşilgül, N., Kılıç, Bilal
Publication Date:	2019
Publication Place	- TÜBİTAK
Subject	BODIPY, Photosensitizer, Photodynamic therapy, Singlet oxygen, Near-IR photosensitizer
Type	Periodical
Language	English
Digital	Yes
Manuscript	No
Library:	Özyeğin University
Library Asset ID	1300-0527
Record ID	9bf187f8-3237-465a-b9ca-2c1810e2ab3c
Library Location	Professional Flight Program
Date	2019
Notes	Department of Chemistry, Bilkent University ; UNAM, Bilkent University ; Faculty of Aviation and Aeronautical Science, Ozyegin University
Sample Text	A series of novel BODIPY-bearing electron-withdrawing groups at the meso position are reported here. According to the optical measurements, it may be clearly seen that the introduction of electron-donating groups into 3,5-positions and the presence of electron-withdrawing groups at the meso position of the BODIPY core resulted in spectacular bathochromic shifts (up to similar to 304 nm), and the projected photosensitizers had absorption bands in the therapeutic window of the electromagnetic spectrum (600-900 nm). The absorption maxima of compounds 4, 5, 6, and 7 were at 886 nm, 890 nm, 760 nm, and 761 nm, respectively. The singlet oxygen generation experiments revealed that compounds 6 and 7, with high singlet oxygen quantum yields (0.52 and 0.93, respectively), were excellent and promising candidates for photodynamic therapy. The singlet oxygen quantum yield of 0.93 was the highest reported value so far for BODIPY-based photosensitizers.
Cilt	43

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Özyeğin University

An exploration of new avenues regarding deep tissue penetration and higher singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic therapy

Author Yeşilgül, N., Kılıç, Bilal

Publication Date 2019

Publication Place - TÜBİTAK

Subject BODIPY, Photosensitizer, Photodynamic therapy, Singlet oxygen, Near-IR photosensitizer

Type Periodical

Language English

Digital Yes

Manuscript No

Library Özyeğin University

Library Asset ID 1300-0527

Record ID 9bf187f8-3237-465a-b9ca-2c1810e2ab3c

Library Location Professional Flight Program

Date 2019

Notes Department of Chemistry, Bilkent University ; UNAM, Bilkent University ; Faculty of Aviation and Aeronautical Science, Ozyegin University

Sample Text A series of novel BODIPY-bearing electron-withdrawing groups at the meso position are reported here. According to the optical measurements, it may be clearly seen that the introduction of electron-donating groups into 3,5-positions and the presence of electron-withdrawing groups at the meso position of the BODIPY core resulted in spectacular bathochromic shifts (up to similar to 304 nm), and the projected photosensitizers had absorption bands in the therapeutic window of the electromagnetic spectrum (600-900 nm). The absorption maxima of compounds 4, 5, 6, and 7 were at 886 nm, 890 nm, 760 nm, and 761 nm, respectively. The singlet oxygen generation experiments revealed that compounds 6 and 7, with high singlet oxygen quantum yields (0.52 and 0.93, respectively), were excellent and promising candidates for photodynamic therapy. The singlet oxygen quantum yield of 0.93 was the highest reported value so far for BODIPY-based photosensitizers.

Cilt 43