Polyethylenimine modified and non-modified polymeric micelles used for nasal administration of carvedilol

Name: Polyethylenimine modified and non-modified polymeric micelles used for nasal administration of carvedilol
Author: Kahraman, E., Karagöz, Ayşe, Dinçer, S., Özsoy, Y.

İsim	Polyethylenimine modified and non-modified polymeric micelles used for nasal administration of carvedilol
Yazar	Kahraman, E., Karagöz, Ayşe, Dinçer, S., Özsoy, Y.
Basım Tarihi:	2015
Basım Yeri	- American Scientific Publishers
Konu	Polymeric micelle, Nasal permeation, Polyethylenimine (PEI), Poly(L-lactide)-block-methoxy poly(ethylene glycol)5000 (PLL-b-mPEG5000) micelles, Carvedilol
Tür	Süreli Yayın
Dil	İngilizce
Dijital	Evet
Yazma	Hayır
Kütüphane:	Özyeğin Üniversitesi
Demirbaş Numarası	1550-7041
Kayıt Numarası	59db418e-7b0f-4e9a-977d-92acab4e41e3
Tarih	2015
Notlar	Due to copyright restrictions, the access to the full text of this article is only available via subscription.
Örnek Metin	This study evaluates the ability of polyethylenimine-modified and non-modified polymeric micelles to enhance permeation through the nasal mucosa for a highly hydrophobic model drug. Carvedilol was loaded into polyethylenimine-modified and non-modified micelles by direct dissolution. Formulations were characterised by critical micelle concentration, micelle particle size and distribution, zeta potential, morphological structure and entrapment efficiency. The drug entrapment efficiency was determined to be as high as 77.14%, while micelle particle sizes and zeta potentials were within the range of 140.0-279.9 nm and (-40.6)-(+25.9) mV, respectively. In vitro studies showed 100% release of carvedilol from micelles in 120 hours. Ex vivo permeation studies showed that the drug in polyethylenimine non-modified micelles passed more efficiently than the drug in polyethylenimine modified micelles. These results demonstrated that polyethylenimine modified micelles did not significantly affect the permeation of the drug when compared to polyethylenimine non-modified micelles. On the contrary, the drug in poly(L-lactide)-block-methoxy poly(ethylene glycol) 5000 micelles, the polyethylenimine non-modified micelles, showed the highest permeation rate through bovine nasal mucosa. In conclusion, poly(L-lactide)-block-methoxy poly(ethylene glycol) 5000 polymeric micelles maybe useful as novel drug carriers that increase the permeation through the nasal mucosa.
DOI	10.1166/jbn.2015.1915
Cilt	11

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Polyethylenimine modified and non-modified polymeric micelles used for nasal administration of carvedilol

Yazar Kahraman, E., Karagöz, Ayşe, Dinçer, S., Özsoy, Y.

Basım Tarihi 2015

Basım Yeri - American Scientific Publishers

Konu Polymeric micelle, Nasal permeation, Polyethylenimine (PEI), Poly(L-lactide)-block-methoxy poly(ethylene glycol)5000 (PLL-b-mPEG5000) micelles, Carvedilol

Tür Süreli Yayın

Dil İngilizce

Dijital Evet

Yazma Hayır

Kütüphane Özyeğin Üniversitesi

Demirbaş Numarası 1550-7041

Kayıt Numarası 59db418e-7b0f-4e9a-977d-92acab4e41e3

Tarih 2015

Notlar Due to copyright restrictions, the access to the full text of this article is only available via subscription.

Örnek Metin This study evaluates the ability of polyethylenimine-modified and non-modified polymeric micelles to enhance permeation through the nasal mucosa for a highly hydrophobic model drug. Carvedilol was loaded into polyethylenimine-modified and non-modified micelles by direct dissolution. Formulations were characterised by critical micelle concentration, micelle particle size and distribution, zeta potential, morphological structure and entrapment efficiency. The drug entrapment efficiency was determined to be as high as 77.14%, while micelle particle sizes and zeta potentials were within the range of 140.0-279.9 nm and (-40.6)-(+25.9) mV, respectively. In vitro studies showed 100% release of carvedilol from micelles in 120 hours. Ex vivo permeation studies showed that the drug in polyethylenimine non-modified micelles passed more efficiently than the drug in polyethylenimine modified micelles. These results demonstrated that polyethylenimine modified micelles did not significantly affect the permeation of the drug when compared to polyethylenimine non-modified micelles. On the contrary, the drug in poly(L-lactide)-block-methoxy poly(ethylene glycol) 5000 micelles, the polyethylenimine non-modified micelles, showed the highest permeation rate through bovine nasal mucosa. In conclusion, poly(L-lactide)-block-methoxy poly(ethylene glycol) 5000 polymeric micelles maybe useful as novel drug carriers that increase the permeation through the nasal mucosa.

DOI 10.1166/jbn.2015.1915

Cilt 11