Back to Search

Polyethylenimine modified and non-modified polymeric micelles used for nasal administration of carvedilol

Title	Polyethylenimine modified and non-modified polymeric micelles used for nasal administration of carvedilol
Author	Kahraman, E., Karagöz, Ayşe, Dinçer, S., Özsoy, Y.
Publication Date:	2015
Publication Place	- American Scientific Publishers
Subject	Polymeric micelle, Nasal permeation, Polyethylenimine (PEI), Poly(L-lactide)-block-methoxy poly(ethylene glycol)5000 (PLL-b-mPEG5000) micelles, Carvedilol
Type	Periodical
Language	English
Digital	Yes
Manuscript	No
Library:	Özyeğin University
Library Asset ID	1550-7041
Record ID	59db418e-7b0f-4e9a-977d-92acab4e41e3
Date	2015
Notes	Due to copyright restrictions, the access to the full text of this article is only available via subscription.
Sample Text	This study evaluates the ability of polyethylenimine-modified and non-modified polymeric micelles to enhance permeation through the nasal mucosa for a highly hydrophobic model drug. Carvedilol was loaded into polyethylenimine-modified and non-modified micelles by direct dissolution. Formulations were characterised by critical micelle concentration, micelle particle size and distribution, zeta potential, morphological structure and entrapment efficiency. The drug entrapment efficiency was determined to be as high as 77.14%, while micelle particle sizes and zeta potentials were within the range of 140.0-279.9 nm and (-40.6)-(+25.9) mV, respectively. In vitro studies showed 100% release of carvedilol from micelles in 120 hours. Ex vivo permeation studies showed that the drug in polyethylenimine non-modified micelles passed more efficiently than the drug in polyethylenimine modified micelles. These results demonstrated that polyethylenimine modified micelles did not significantly affect the permeation of the drug when compared to polyethylenimine non-modified micelles. On the contrary, the drug in poly(L-lactide)-block-methoxy poly(ethylene glycol) 5000 micelles, the polyethylenimine non-modified micelles, showed the highest permeation rate through bovine nasal mucosa. In conclusion, poly(L-lactide)-block-methoxy poly(ethylene glycol) 5000 polymeric micelles maybe useful as novel drug carriers that increase the permeation through the nasal mucosa.
DOI	10.1166/jbn.2015.1915
Cilt	11

View in source Özyeğin University Özyeğin University - Historical works, archives, and periodicals search engine

Özyeğin University

Polyethylenimine modified and non-modified polymeric micelles used for nasal administration of carvedilol

Author Kahraman, E., Karagöz, Ayşe, Dinçer, S., Özsoy, Y.

Publication Date 2015

Publication Place - American Scientific Publishers

Subject Polymeric micelle, Nasal permeation, Polyethylenimine (PEI), Poly(L-lactide)-block-methoxy poly(ethylene glycol)5000 (PLL-b-mPEG5000) micelles, Carvedilol

Type Periodical

Language English

Digital Yes

Manuscript No

Library Özyeğin University

Library Asset ID 1550-7041

Record ID 59db418e-7b0f-4e9a-977d-92acab4e41e3

Date 2015

Notes Due to copyright restrictions, the access to the full text of this article is only available via subscription.

Sample Text This study evaluates the ability of polyethylenimine-modified and non-modified polymeric micelles to enhance permeation through the nasal mucosa for a highly hydrophobic model drug. Carvedilol was loaded into polyethylenimine-modified and non-modified micelles by direct dissolution. Formulations were characterised by critical micelle concentration, micelle particle size and distribution, zeta potential, morphological structure and entrapment efficiency. The drug entrapment efficiency was determined to be as high as 77.14%, while micelle particle sizes and zeta potentials were within the range of 140.0-279.9 nm and (-40.6)-(+25.9) mV, respectively. In vitro studies showed 100% release of carvedilol from micelles in 120 hours. Ex vivo permeation studies showed that the drug in polyethylenimine non-modified micelles passed more efficiently than the drug in polyethylenimine modified micelles. These results demonstrated that polyethylenimine modified micelles did not significantly affect the permeation of the drug when compared to polyethylenimine non-modified micelles. On the contrary, the drug in poly(L-lactide)-block-methoxy poly(ethylene glycol) 5000 micelles, the polyethylenimine non-modified micelles, showed the highest permeation rate through bovine nasal mucosa. In conclusion, poly(L-lactide)-block-methoxy poly(ethylene glycol) 5000 polymeric micelles maybe useful as novel drug carriers that increase the permeation through the nasal mucosa.

DOI 10.1166/jbn.2015.1915

Cilt 11