A double-needle gold-silver electrodes continuous glucose monitoring device

Name: A double-needle gold-silver electrodes continuous glucose monitoring device
Author: Hassine, Chedia Ben Ali, Tekin, A.

İsim	A double-needle gold-silver electrodes continuous glucose monitoring device
Yazar	Hassine, Chedia Ben Ali, Tekin, A.
Basım Tarihi:	2023-06
Basım Yeri	- Elsevier
Konu	Continuous glucose monitoring (CGM), Ferrocene, Glucose oxidase, Two needles
Tür	Süreli Yayın
Dil	İngilizce
Dijital	Evet
Yazma	Hayır
Kütüphane:	Özyeğin Üniversitesi
Demirbaş Numarası	1959-0318
Kayıt Numarası	53015e9d-12dd-414d-8c59-6fa38c9b9a8a
Tarih	2023-06
Örnek Metin	Objectives: Diabetes is a serious, long-term disease and the use of continuous glucose monitoring sensors can reduce reliance on other painful invasive blood testing methods such as the finger blood glucose test. According to our work, a low-cost continuous glucose sensor has been developed based on electrochemical measurement techniques. Materials: The sensor is based on a two needles system; a gold and a silver electrode are integrated into a circular shaped electronic printed circuit board (PCB). The sensing part is based on biological electrochemical measurements. Glucose oxidase (Gox) was used as the active sensing element and ferrocene (Fc) as a mediator. Simple and low-cost coating methods were used; these methods are self-assembled monolayers and deep coating. This will reduce the final cost of the sensor as no expensive technique was used. The electrical subsystem contains a low-noise and low-power trans-impedance front-end as well as a single-chip low-power Bluetooth microcontroller with a 12-bit Analog-to-Digital Converter (ADC). Results: The sensor was tested in various concentrations of glucose. As a result of initial in vitro experiments, detailed analytical performance metrics are presented. The device has consistently shown a sensitivity of 3.059 mV/(mg/dl) reading with a linear range of 0-400 mg/dl. Conclusion: The proposed study shows promising results for glucose detection. Thus, this type of sensor can be used for different analyzes targeting biological applications after further investigations and analysis.
DOI	10.1016/j.irbm.2023.100752
Cilt	44

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A double-needle gold-silver electrodes continuous glucose monitoring device

Yazar Hassine, Chedia Ben Ali, Tekin, A.

Basım Tarihi 2023-06

Basım Yeri - Elsevier

Konu Continuous glucose monitoring (CGM), Ferrocene, Glucose oxidase, Two needles

Tür Süreli Yayın

Dil İngilizce

Dijital Evet

Yazma Hayır

Kütüphane Özyeğin Üniversitesi

Demirbaş Numarası 1959-0318

Kayıt Numarası 53015e9d-12dd-414d-8c59-6fa38c9b9a8a

Tarih 2023-06

Örnek Metin Objectives: Diabetes is a serious, long-term disease and the use of continuous glucose monitoring sensors can reduce reliance on other painful invasive blood testing methods such as the finger blood glucose test. According to our work, a low-cost continuous glucose sensor has been developed based on electrochemical measurement techniques. Materials: The sensor is based on a two needles system; a gold and a silver electrode are integrated into a circular shaped electronic printed circuit board (PCB). The sensing part is based on biological electrochemical measurements. Glucose oxidase (Gox) was used as the active sensing element and ferrocene (Fc) as a mediator. Simple and low-cost coating methods were used; these methods are self-assembled monolayers and deep coating. This will reduce the final cost of the sensor as no expensive technique was used. The electrical subsystem contains a low-noise and low-power trans-impedance front-end as well as a single-chip low-power Bluetooth microcontroller with a 12-bit Analog-to-Digital Converter (ADC). Results: The sensor was tested in various concentrations of glucose. As a result of initial in vitro experiments, detailed analytical performance metrics are presented. The device has consistently shown a sensitivity of 3.059 mV/(mg/dl) reading with a linear range of 0-400 mg/dl. Conclusion: The proposed study shows promising results for glucose detection. Thus, this type of sensor can be used for different analyzes targeting biological applications after further investigations and analysis.

DOI 10.1016/j.irbm.2023.100752

Cilt 44