High shear rate propulsion of acoustic microrobots in complex biological fluids

Name: High shear rate propulsion of acoustic microrobots in complex biological fluids
Author: Aghakhani, A., Pena-Francesch, A., Bozuyuk, U., Çetin, Hakan, Wrede, P., Sitti, M.

İsim	High shear rate propulsion of acoustic microrobots in complex biological fluids
Yazar	Aghakhani, A., Pena-Francesch, A., Bozuyuk, U., Çetin, Hakan, Wrede, P., Sitti, M.
Basım Tarihi:	2022-03-11
Basım Yeri	- American Association for the Advancement of Science
Tür	Süreli Yayın
Dil	İngilizce
Dijital	Evet
Yazma	Hayır
Kütüphane:	Özyeğin Üniversitesi
Demirbaş Numarası	2375-2548
Kayıt Numarası	7ae83f5c-6779-4924-9efb-c39237403900
Tarih	2022-03-11
Örnek Metin	Untethered microrobots offer a great promise for localized targeted therapy in hard-to-access spaces in our body. Despite recent advancements, most microrobot propulsion capabilities have been limited to homogenous Newtonian fluids. However, the biological fluids present in our body are heterogeneous and have shear rate–dependent rheological properties, which limit the propulsion of microrobots using conventional designs and actuation methods. We propose an acoustically powered microrobotic system, consisting of a three-dimensionally printed 30-micrometer-diameter hollow body with an oscillatory microbubble, to generate high shear rate fluidic flow for propulsion in complex biofluids. The acoustically induced microstreaming flow leads to distinct surface-slipping and puller-type propulsion modes in Newtonian and non-Newtonian fluids, respectively. We demonstrate efficient propulsion of the microrobots in diverse biological fluids, including in vitro navigation through mucus layers on biologically relevant three-dimensional surfaces. The microrobot design and high shear rate propulsion mechanism discussed herein could open new possibilities to deploy microrobots in complex biofluids toward minimally invasive targeted therapy.
DOI	10.1126/sciadv.abm5126
Cilt	8

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High shear rate propulsion of acoustic microrobots in complex biological fluids

Yazar Aghakhani, A., Pena-Francesch, A., Bozuyuk, U., Çetin, Hakan, Wrede, P., Sitti, M.

Basım Tarihi 2022-03-11

Basım Yeri - American Association for the Advancement of Science

Tür Süreli Yayın

Dil İngilizce

Dijital Evet

Yazma Hayır

Kütüphane Özyeğin Üniversitesi

Demirbaş Numarası 2375-2548

Kayıt Numarası 7ae83f5c-6779-4924-9efb-c39237403900

Tarih 2022-03-11

Örnek Metin Untethered microrobots offer a great promise for localized targeted therapy in hard-to-access spaces in our body. Despite recent advancements, most microrobot propulsion capabilities have been limited to homogenous Newtonian fluids. However, the biological fluids present in our body are heterogeneous and have shear rate–dependent rheological properties, which limit the propulsion of microrobots using conventional designs and actuation methods. We propose an acoustically powered microrobotic system, consisting of a three-dimensionally printed 30-micrometer-diameter hollow body with an oscillatory microbubble, to generate high shear rate fluidic flow for propulsion in complex biofluids. The acoustically induced microstreaming flow leads to distinct surface-slipping and puller-type propulsion modes in Newtonian and non-Newtonian fluids, respectively. We demonstrate efficient propulsion of the microrobots in diverse biological fluids, including in vitro navigation through mucus layers on biologically relevant three-dimensional surfaces. The microrobot design and high shear rate propulsion mechanism discussed herein could open new possibilities to deploy microrobots in complex biofluids toward minimally invasive targeted therapy.

DOI 10.1126/sciadv.abm5126

Cilt 8