Author
Yaraş, Y. S., Gündüz, A. B., Sağlam, G., Ölçer, S., Civitçi, F., Baris, İ., Yaralıoğlu, Göksen Göksenin, Urey, H.
Publication Date
2017-11
Publication Place
-
SPIE
Subject
Fiber optic sensor, Blood coagulation, Activated partial thromboplastin time, Point-of-care, Lab-on-a-chip
Type
Periodical
Language
English
Digital
Yes
Manuscript
No
Library
Özyeğin University
Library Asset ID
1083-3668
Record ID
f85f5efa-0f63-4c9c-9c20-5d665ae4d55c
Library Location
Electrical & Electronics Engineering
Date
2017-11
Sample Text
In clinics, blood coagulation time measurements are performed using mechanical measurements with blood plasma. Such measurements are challenging to do in a lab-on-a-chip (LoC) system using a small volume of whole blood. Existing LoC systems use indirect measurement principles employing optical or electrochemical methods. We developed an LoC system using mechanical measurements with a small volume of whole blood without requiring sample preparation. The measurement is performed in a microfluidic channel where two fibers are placed inline with a small gap in between. The first fiber operates near its mechanical resonance using remote magnetic actuation and immersed in the sample. The second fiber is a pick-up fiber acting as an optical sensor. The microfluidic channel is engineered innovatively such that the blood does not block the gap between the vibrating fiber and the pick-up fiber, resulting in high signal-to-noise ratio optical output. The control plasma test results matched well with the plasma manufacturer’s datasheet. Activated-partial-thromboplastin-time tests were successfully performed also with human whole blood samples, and the method is proven to be effective. Simplicity of the cartridge design and cost of readily available materials enable a low-cost point-of-care device for blood coagulation measurements.
DOI
10.1117/1.JBO.22.11.117001
Cilt
22
