Author
Cakmak, O., Kılınç, N., Ermek, E., Mostafazadeh, A., Elbuken, Ç., Yaralıoğlu, Göksen Göksenin, Urey, H.
Publication Date
2014
Publication Place
-
IEEE
Subject
Coagulation, Lab-on-a-chip, Microfluidics, Microsensors
Type
Document
Language
English
Digital
Yes
Manuscript
No
Library
Özyeğin University
Library Asset ID
978-1-4799-3509-3
Record ID
71016d41-a529-42c2-9d87-0de168342572
Library Location
Electrical & Electronics Engineering
Date
2014
Notes
Due to copyright restrictions, the access to the full text of this article is only available via subscription.
Sample Text
This paper reports a MEMS-based sensor array enabling multiple clot-time tests in one disposable microfluidic cartridge using plasma. The versatile LoC (Lab-on-Chip) platform technology is demonstrated here for real-time coagulation tests (activated Partial Thrompoblastin Time (aPTT) and Prothrombin Time (PT)). The system has a reader unit and a disposable cartridge. The reader has no electrical connections to the cartridge, which consists of multiple microfluidic channels and MEMS microcantilevers placed in each channel. Microcantilevers are made of electro-plated nickel and actuated remotely using an external electro-coil. The read-out is also conducted remotely by a laser and the phase of the MEMS oscillator is monitored real-time. The system is capable of monitoring coagulation time with a precision estimated at 0.1sec.
DOI
10.1109/MEMSYS.2014.6765643
