Flexural wave-based soft attractor walls for trapping microparticles and cells

Name: Flexural wave-based soft attractor walls for trapping microparticles and cells
Author: Aghakhani, A., Çetin, Hakan, Erkoc, P., Tombak, G. I., Sitti, M.

İsim	Flexural wave-based soft attractor walls for trapping microparticles and cells
Yazar	Aghakhani, A., Çetin, Hakan, Erkoc, P., Tombak, G. I., Sitti, M.
Basım Tarihi:	2021-02-07
Basım Yeri	- Royal Society of Chemistry
Tür	Süreli Yayın
Dil	İngilizce
Dijital	Evet
Yazma	Hayır
Kütüphane:	Özyeğin Üniversitesi
Demirbaş Numarası	1473-0197
Kayıt Numarası	75720927-58a7-4201-b7bd-4125989a3161
Tarih	2021-02-07
Notlar	Max Planck Society ; European Research Council (ERC)
Örnek Metin	Acoustic manipulation of microparticles and cells, called acoustophoresis, inside microfluidic systems has significant potential in biomedical applications. In particular, using acoustic radiation force to push microscopic objects toward the wall surfaces has an important role in enhancing immunoassays, particle sensors, and recently microrobotics. In this paper, we report a flexural-wave based acoustofluidic system for trapping micron-sized particles and cells at the soft wall boundaries. By exciting a standard microscope glass slide (1 mm thick) at its resonance frequencies <200 kHz, we show the wall-trapping action in sub-millimeter-size rectangular and circular cross-sectional channels. For such low-frequency excitation, the acoustic wavelength can range from 10-150 times the microchannel width, enabling a wide design space for choosing the channel width and position on the substrate. Using the system-level acousto-structural simulations, we confirm the acoustophoretic motion of particles near the walls, which is governed by the competing acoustic radiation and streaming forces. Finally, we investigate the performance of the wall-trapping acoustofluidic setup in attracting the motile cells, such asChlamydomonas reinhardtiimicroalgae, toward the soft boundaries. Furthermore, the rotation of microalgae at the sidewalls and trap-escape events under pulsed ultrasound are demonstrated. The flexural-wave driven acoustofluidic system described here provides a biocompatible, versatile, and label-free approach to attract particles and cells toward the soft walls.
DOI	10.1039/d0lc00865f
Cilt	21

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Flexural wave-based soft attractor walls for trapping microparticles and cells

Yazar Aghakhani, A., Çetin, Hakan, Erkoc, P., Tombak, G. I., Sitti, M.

Basım Tarihi 2021-02-07

Basım Yeri - Royal Society of Chemistry

Tür Süreli Yayın

Dil İngilizce

Dijital Evet

Yazma Hayır

Kütüphane Özyeğin Üniversitesi

Demirbaş Numarası 1473-0197

Kayıt Numarası 75720927-58a7-4201-b7bd-4125989a3161

Tarih 2021-02-07

Notlar Max Planck Society ; European Research Council (ERC)

Örnek Metin Acoustic manipulation of microparticles and cells, called acoustophoresis, inside microfluidic systems has significant potential in biomedical applications. In particular, using acoustic radiation force to push microscopic objects toward the wall surfaces has an important role in enhancing immunoassays, particle sensors, and recently microrobotics. In this paper, we report a flexural-wave based acoustofluidic system for trapping micron-sized particles and cells at the soft wall boundaries. By exciting a standard microscope glass slide (1 mm thick) at its resonance frequencies <200 kHz, we show the wall-trapping action in sub-millimeter-size rectangular and circular cross-sectional channels. For such low-frequency excitation, the acoustic wavelength can range from 10-150 times the microchannel width, enabling a wide design space for choosing the channel width and position on the substrate. Using the system-level acousto-structural simulations, we confirm the acoustophoretic motion of particles near the walls, which is governed by the competing acoustic radiation and streaming forces. Finally, we investigate the performance of the wall-trapping acoustofluidic setup in attracting the motile cells, such asChlamydomonas reinhardtiimicroalgae, toward the soft boundaries. Furthermore, the rotation of microalgae at the sidewalls and trap-escape events under pulsed ultrasound are demonstrated. The flexural-wave driven acoustofluidic system described here provides a biocompatible, versatile, and label-free approach to attract particles and cells toward the soft walls.

DOI 10.1039/d0lc00865f

Cilt 21