Preparation of molecularly imprinted metoprolol sensor from poly(aniline-co-p-toluene sulfonic acid)

Name: Preparation of molecularly imprinted metoprolol sensor from poly(aniline-co-p-toluene sulfonic acid)
Author: Güngör, Ö., Hassine, Chedia Ben Ali, Burç, M., Köytepe, S., Duran, S. T.

İsim	Preparation of molecularly imprinted metoprolol sensor from poly(aniline-co-p-toluene sulfonic acid)
Yazar	Güngör, Ö., Hassine, Chedia Ben Ali, Burç, M., Köytepe, S., Duran, S. T.
Basım Tarihi:	2022
Basım Yeri	- Center of Excellence in Electrochemistry
Konu	Metoprolol, Electropolymerization, Molecularly imprinted electrode, Sensor, Voltammetry
Tür	Süreli Yayın
Dil	İngilizce
Dijital	Evet
Yazma	Hayır
Kütüphane:	Özyeğin Üniversitesi
Demirbaş Numarası	2008-4226
Kayıt Numarası	4ec99257-b888-4634-94e7-3b8fba5f2b85
Tarih	2022
Notlar	İnönü University
Örnek Metin	In this study, the metoprolol (MTP), which is a beta-blocker class molecule used in hypertension treatment, was determined by modifying the glassy carbon electrode (GCE) with a molecular imprinting technique. Firstly, p-toluene sulfonic acid (PTSA) and aniline (AN) were co-electropolymerized in the presence of MTP as a template molecule on GCE and MTP contained poly(aniline-co-p-toluene sulfonic acid) (p(AN-co-PTSA)) film was obtained. Then, the template metoprolol molecule was desorbed from the conductive p(AN-co-PTSA) film structure on the GCE surface using hydrochloric acid. Obtained molecularly imprinted electrodes were used to determine MTP by the square wave voltammetry (SWV) method. The modified electrodes obtained showed a correlation coefficient (R²) of 0.9995 in the 40-1500 µM MTP concentration range. The limit of detection (LOD) and the limit of quantification (LOQ) of the p(AN-co-PTSA) film modified MTP electrodes were 37.9 µM and 126.3 µM, respectively. A standard deviation of 1.33% was observed for the first three replicates with the same modified electrode. For the time reproduced electrodes, stable reproducibility was achieved between the first electrode result and the tenth electrode result. For the modified MTP electrode, the relative standard deviation (RSD%) value was calculated to be 2.53%. As result, the molecularly imprinted electrodes prepared with p(AN-co-PTSA) film have low response time, high reproducibility, good stability, and high selectivity for the determination of MTP.
Cilt	14

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Preparation of molecularly imprinted metoprolol sensor from poly(aniline-co-p-toluene sulfonic acid)

Yazar Güngör, Ö., Hassine, Chedia Ben Ali, Burç, M., Köytepe, S., Duran, S. T.

Basım Tarihi 2022

Basım Yeri - Center of Excellence in Electrochemistry

Konu Metoprolol, Electropolymerization, Molecularly imprinted electrode, Sensor, Voltammetry

Tür Süreli Yayın

Dil İngilizce

Dijital Evet

Yazma Hayır

Kütüphane Özyeğin Üniversitesi

Demirbaş Numarası 2008-4226

Kayıt Numarası 4ec99257-b888-4634-94e7-3b8fba5f2b85

Tarih 2022

Notlar İnönü University

Örnek Metin In this study, the metoprolol (MTP), which is a beta-blocker class molecule used in hypertension treatment, was determined by modifying the glassy carbon electrode (GCE) with a molecular imprinting technique. Firstly, p-toluene sulfonic acid (PTSA) and aniline (AN) were co-electropolymerized in the presence of MTP as a template molecule on GCE and MTP contained poly(aniline-co-p-toluene sulfonic acid) (p(AN-co-PTSA)) film was obtained. Then, the template metoprolol molecule was desorbed from the conductive p(AN-co-PTSA) film structure on the GCE surface using hydrochloric acid. Obtained molecularly imprinted electrodes were used to determine MTP by the square wave voltammetry (SWV) method. The modified electrodes obtained showed a correlation coefficient (R²) of 0.9995 in the 40-1500 µM MTP concentration range. The limit of detection (LOD) and the limit of quantification (LOQ) of the p(AN-co-PTSA) film modified MTP electrodes were 37.9 µM and 126.3 µM, respectively. A standard deviation of 1.33% was observed for the first three replicates with the same modified electrode. For the time reproduced electrodes, stable reproducibility was achieved between the first electrode result and the tenth electrode result. For the modified MTP electrode, the relative standard deviation (RSD%) value was calculated to be 2.53%. As result, the molecularly imprinted electrodes prepared with p(AN-co-PTSA) film have low response time, high reproducibility, good stability, and high selectivity for the determination of MTP.

Cilt 14