Coagulation measurement from whole blood using vibrating optical fiber in a disposable cartridge

Name: Coagulation measurement from whole blood using vibrating optical fiber in a disposable cartridge
Author: Yaraş, Y. S., Gündüz, A. B., Sağlam, G., Ölçer, S., Civitçi, F., Baris, İ., Yaralıoğlu, Göksen Göksenin, Urey, H.

İsim	Coagulation measurement from whole blood using vibrating optical fiber in a disposable cartridge
Yazar	Yaraş, Y. S., Gündüz, A. B., Sağlam, G., Ölçer, S., Civitçi, F., Baris, İ., Yaralıoğlu, Göksen Göksenin, Urey, H.
Basım Tarihi:	2017-11
Basım Yeri	- SPIE
Konu	Fiber optic sensor, Blood coagulation, Activated partial thromboplastin time, Point-of-care, Lab-on-a-chip
Tür	Süreli Yayın
Dil	İngilizce
Dijital	Evet
Yazma	Hayır
Kütüphane:	Özyeğin Üniversitesi
Demirbaş Numarası	1083-3668
Kayıt Numarası	f85f5efa-0f63-4c9c-9c20-5d665ae4d55c
Lokasyon	Electrical & Electronics Engineering
Tarih	2017-11
Örnek Metin	In clinics, blood coagulation time measurements are performed using mechanical measurements with blood plasma. Such measurements are challenging to do in a lab-on-a-chip (LoC) system using a small volume of whole blood. Existing LoC systems use indirect measurement principles employing optical or electrochemical methods. We developed an LoC system using mechanical measurements with a small volume of whole blood without requiring sample preparation. The measurement is performed in a microfluidic channel where two fibers are placed inline with a small gap in between. The first fiber operates near its mechanical resonance using remote magnetic actuation and immersed in the sample. The second fiber is a pick-up fiber acting as an optical sensor. The microfluidic channel is engineered innovatively such that the blood does not block the gap between the vibrating fiber and the pick-up fiber, resulting in high signal-to-noise ratio optical output. The control plasma test results matched well with the plasma manufacturer’s datasheet. Activated-partial-thromboplastin-time tests were successfully performed also with human whole blood samples, and the method is proven to be effective. Simplicity of the cartridge design and cost of readily available materials enable a low-cost point-of-care device for blood coagulation measurements.
DOI	10.1117/1.JBO.22.11.117001
Cilt	22

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Coagulation measurement from whole blood using vibrating optical fiber in a disposable cartridge

Yazar Yaraş, Y. S., Gündüz, A. B., Sağlam, G., Ölçer, S., Civitçi, F., Baris, İ., Yaralıoğlu, Göksen Göksenin, Urey, H.

Basım Tarihi 2017-11

Basım Yeri - SPIE

Konu Fiber optic sensor, Blood coagulation, Activated partial thromboplastin time, Point-of-care, Lab-on-a-chip

Tür Süreli Yayın

Dil İngilizce

Dijital Evet

Yazma Hayır

Kütüphane Özyeğin Üniversitesi

Demirbaş Numarası 1083-3668

Kayıt Numarası f85f5efa-0f63-4c9c-9c20-5d665ae4d55c

Lokasyon Electrical & Electronics Engineering

Tarih 2017-11

Örnek Metin In clinics, blood coagulation time measurements are performed using mechanical measurements with blood plasma. Such measurements are challenging to do in a lab-on-a-chip (LoC) system using a small volume of whole blood. Existing LoC systems use indirect measurement principles employing optical or electrochemical methods. We developed an LoC system using mechanical measurements with a small volume of whole blood without requiring sample preparation. The measurement is performed in a microfluidic channel where two fibers are placed inline with a small gap in between. The first fiber operates near its mechanical resonance using remote magnetic actuation and immersed in the sample. The second fiber is a pick-up fiber acting as an optical sensor. The microfluidic channel is engineered innovatively such that the blood does not block the gap between the vibrating fiber and the pick-up fiber, resulting in high signal-to-noise ratio optical output. The control plasma test results matched well with the plasma manufacturer’s datasheet. Activated-partial-thromboplastin-time tests were successfully performed also with human whole blood samples, and the method is proven to be effective. Simplicity of the cartridge design and cost of readily available materials enable a low-cost point-of-care device for blood coagulation measurements.

DOI 10.1117/1.JBO.22.11.117001

Cilt 22