Blood coagulation time measurement using a 1μL of whole blood on a TE mode BAW resonator

Name: Blood coagulation time measurement using a 1μL of whole blood on a TE mode BAW resonator
Author: Majidi, Negar, Sobhani, M. R., Yaralıoğlu, Göksen Göksenin

İsim	Blood coagulation time measurement using a 1μL of whole blood on a TE mode BAW resonator
Yazar	Majidi, Negar, Sobhani, M. R., Yaralıoğlu, Göksen Göksenin
Basım Tarihi:	2018-12-20
Basım Yeri	- IEEE
Konu	Acoustic reflections, BAW resonator, Coagulation, Component, ZnO
Tür	Belge
Dil	İngilizce
Dijital	Evet
Yazma	Hayır
Kütüphane:	Özyeğin Üniversitesi
Demirbaş Numarası	978-153863425-7
Kayıt Numarası	c352c39c-65c1-4a05-9e44-2a2beb01c791
Lokasyon	Electrical & Electronics Engineering
Tarih	2018-12-20
Notlar	Ozyegin University ; University of Alberta
Örnek Metin	This paper presents a possible way to blood coagulation time measurement using a TE (Thickness Extensions) mode BAW (Bulk Acoustic Wave) resonator which requires as low as 1 micro-liter of whole blood. The blood sample is placed on the top surface of a glass plate where a compressional ultrasonic transducer is fabricated on the bottom surface. The transducer is made of 8 μm thick zinc oxide (ZnO) thin film that has a thickness resonance frequency around 400 MHz. The transducer generates compressional (longitudinal) acoustic wave inside the piezoelectric thin film and glass substrate. The acoustic waves are mostly reflected and trapped inside the device from both sides of it; 1) the glass/liquid (blood) interface, and 2) the transducer/air interface. Most of the acoustic waves are reflected from the second interface because of the higher impedance mismatch, while the reflections from the first boundary are related to impedance (mechanical properties) of the liquid sample or blood. The acoustic impedance of blood changes due to the coagulation process. This affects the reflection coefficient and amplitude of the reflected waves from the blood/glass interface. Thus, the overall acoustic energy trapped inside the bulk film changes over the time which consequently affects the resonator parameters. The blood coagulation time was determined by monitoring the amplitude of the reflected sinusoidal acoustic waves at 400 MHz in the previous work using the same device. However, in this paper we demonstrate the resonance frequency shifts obtained by numerical modeling and practical measurements for a few liquid samples with different mechanical properties. The proposed method has a potential to be used in a low-cost portable coagulation time measurement cartridge which requires only 1μL of whole blood without centrifuging. A simple resonator can be implemented for tracking the resonating frequency to further reduce the size and cost of the device, to make it more suitable for patient self-testing applications.
DOI	10.1109/ULTSYM.2018.8580124
Cilt	2018

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Blood coagulation time measurement using a 1μL of whole blood on a TE mode BAW resonator

Yazar Majidi, Negar, Sobhani, M. R., Yaralıoğlu, Göksen Göksenin

Basım Tarihi 2018-12-20

Basım Yeri - IEEE

Konu Acoustic reflections, BAW resonator, Coagulation, Component, ZnO

Tür Belge

Dil İngilizce

Dijital Evet

Yazma Hayır

Kütüphane Özyeğin Üniversitesi

Demirbaş Numarası 978-153863425-7

Kayıt Numarası c352c39c-65c1-4a05-9e44-2a2beb01c791

Lokasyon Electrical & Electronics Engineering

Tarih 2018-12-20

Notlar Ozyegin University ; University of Alberta

Örnek Metin This paper presents a possible way to blood coagulation time measurement using a TE (Thickness Extensions) mode BAW (Bulk Acoustic Wave) resonator which requires as low as 1 micro-liter of whole blood. The blood sample is placed on the top surface of a glass plate where a compressional ultrasonic transducer is fabricated on the bottom surface. The transducer is made of 8 μm thick zinc oxide (ZnO) thin film that has a thickness resonance frequency around 400 MHz. The transducer generates compressional (longitudinal) acoustic wave inside the piezoelectric thin film and glass substrate. The acoustic waves are mostly reflected and trapped inside the device from both sides of it; 1) the glass/liquid (blood) interface, and 2) the transducer/air interface. Most of the acoustic waves are reflected from the second interface because of the higher impedance mismatch, while the reflections from the first boundary are related to impedance (mechanical properties) of the liquid sample or blood. The acoustic impedance of blood changes due to the coagulation process. This affects the reflection coefficient and amplitude of the reflected waves from the blood/glass interface. Thus, the overall acoustic energy trapped inside the bulk film changes over the time which consequently affects the resonator parameters. The blood coagulation time was determined by monitoring the amplitude of the reflected sinusoidal acoustic waves at 400 MHz in the previous work using the same device. However, in this paper we demonstrate the resonance frequency shifts obtained by numerical modeling and practical measurements for a few liquid samples with different mechanical properties. The proposed method has a potential to be used in a low-cost portable coagulation time measurement cartridge which requires only 1μL of whole blood without centrifuging. A simple resonator can be implemented for tracking the resonating frequency to further reduce the size and cost of the device, to make it more suitable for patient self-testing applications.

DOI 10.1109/ULTSYM.2018.8580124

Cilt 2018